盐酸戊乙奎醚治疗重度有机磷中毒并发呼吸衰竭的临床研究

目的评价盐酸戊乙奎醚治疗重度有机磷中毒并发呼吸衰竭的疗效。方法重度有机磷中毒合并呼吸衰竭者43例纳入研究，盐酸戊乙奎醚治疗组19例，阿托品对照组24例。比较两组患者治疗前后PaO2和氧合指数变化以及两组间24小时、72小时用药总量和胆碱酯酶变化，以及两组间需机械通气的人数和机械通气患者时间及需使用镇静剂的人数。结果两组患者治疗后血气结果改善明显，两组患者需要机械通气人数、达到阿托品化／K托宁化时间及24小时、72小时胆碱酯酶恢复水平均无显著差异，但盐酸戊乙奎醚组24小时及72小时用药量显著少于阿托品组，在需机械通气的患者中，盐酸戊乙奎醚组机械通气时间显著短于阿托品组，需使用镇静剂者亦较少。结论盐酸戊乙奎醚可有效治疗重度有机磷中毒并发呼吸衰竭，与阿托品相比较有一定优势。

Clinical study of penehyclidine hydrochioride in the treatment of respiratory failure caused by severe acute organophosphorus poison. ing.

Objective To evaluate the efficacy of penehyclidine hydrochloride in the treatment of respiratory failure caused by severe acute organophosphorus poisoning. Methods In the treatment group , penehyclidine hydrochloride was used as the anticholinergic agent in the treatment of severe organophosphorus poisoning while atropine was taken in the control group, without any change of other treating methods and agents. Change of blood gas analysis , total amount of anticholinergic agent and recover level of cholinesterase in 24 hours and 72 hours, number of patients whom needs mechanical ventilation and cases of used sedation during mechanical ventilation in the two groups were compared respectively. Results There were no statistically significant differences between the control group and the treatment group in number of patients whom needs mechanical ventilation or the recover level of cholinesterase in 24 hours and 72 hours . But in treatment group, total amount of anticholinergic agent in 24 hours and 72 hours were significantly less than the control group. Length of mechanical ventilation in the treatment group was significantly shorter than which in the control group. Conclusion It is suggested by the result that penehyclidine hy- drochloride is highly effective in treatment of respiratory failure severe caused by acute organophosphorus poisoning .