脑膜瘤中iNOS的表达与意义

目的：探讨诱导型一氧化氮合成酶（inducible nitric oxide synthase，iNOS）在脑膜瘤中的表达和临床意义。方法：采用免疫组织化学SABC方法检测47例脑膜瘤和10例正常脑膜组织中诱导型一氧化氮合成酶的表达并分析其相关性。结果：①正常脑膜中无iNOS，明显低于肿瘤组织，差异有统计学意义（P〈0．05）。②脑膜瘤组织中，iNOS阳性表达率为68．09％；iNOS的表达与患者的年龄、性别和肿瘤部位、大小、形状无关（P〉0．05），各级脑膜瘤组织均有iNOS蛋白阳性表达，其中Ⅰ、Ⅱ、Ⅲ级中分别随病理分级和瘤周水肿分级升高逐渐增高，不同级别脑膜瘤各组间差异均有统计学意义（P〈0．05）。结论：脑膜瘤组织中iNOS的表达与脑膜瘤血管生成和临床病理密切相关，iNOS可作为预测脑膜瘤生物学行为的一项重要指标。

THE EXPRESSION AND CLINICAL SIGNIFICANCE OF INDUCIBLE NITRIC OXIDE SYNTHASE IN MENINGIOMAS

Objective： To study the expression and clinical significance of inducible nitric oxide synthase （iN- OS） in meningiomas. Methods： Forty-seven meningioma tissue and ten human common dura were examined for iNOS expression by immunohistochemical method. Results： （1） The difference of iNOS in meningioma tissues and human common dura was significant （P〈0.05）. （2）The positive expression rate of iNOS was 68.09% in meningioma tissues;iNOS expression was not related with the patients＇ age, sex and the size, location, sign of tumors （P〉0.05）o The expression of iNOS in the grade Ⅰ , Ⅱ . Ⅲ meningmioma gradually increased with the rise of pathological grade and peritumoral brain edema grade of meningioma; and the difference of iNOS in every two groups was significant （P〈0.05）. Conclusion： The expression of iNOS in meningiomas is significantly correlated to tumors＇ angiogenesis and clinicopathology,and it can be taken as an useful marker for predicting the biological behavior of meningioma.