多菌灵复合硫磺悬浮剂的急性毒性研究

目的研究以多菌灵和硫磺为主要成分的悬浮剂的急性毒性，为其毒理安全性评价提供依据。方法按国家标准GB15670-1995进行经口、经皮、吸入毒性、急性皮肤及眼刺激试验、皮肤致敏试验。结果40％多菌灵·硫磺悬浮剂对雌雄性SD大鼠经口LD50分别为4300mg／kg·BW和2710mg／kg·BW；对雌雄性SD大鼠急性经皮LD50〉2000mg／kg·BW；急性吸入LD50〉2000mg／m^3；皮肤刺激反应积分均值为1.0；无急性眼刺激性。皮肤致敏率为0。结论40％多菌灵·硫磺悬浮剂为低毒，无眼刺激性、轻度皮肤刺激性弱致敏性的农药。

Investigation into the acute toxicity of carbendaxim- sulfur complex suspension

Objective To observe the acute toxicity of the carbendazim - sulfur complex SC and provide evidence for assessment of toxicological security of SC. Methods Based on GB15670 - 1995, acute toxicity tests by oral LD50 skin and inhalation, acute irritation toxicity test by skin and eye, and skin sensitization test. Results The oral LDso for the SD female mice of the 40% carbendazim - sulfur complex SC was 4300mg/kg·BW, LD50 was 2710mg/kg·BW for the male mice, be-long to low - toxicity. The degree of the acute dermal toxicity and the oral LC50 for mice of the SC was low. The degree of dermal irritation of the SC to rabbits was also low; the degree of eye irritation of the SC to rabbits was non-irritative. It was low sensitinogen in skin test. Conclusion The toxicity of 40% carbendazim-sulfur complex SC is low, the irritation to skin and eyes of rabbits is mild, thus it is a mild sensitinogen.