| 干扰素a－2b治疗慢性髓性白血病 |
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| 引用本文： | 傅剑锋,王德炳,单福香．江滨,张景云,张丽丽, 赵军,毕加敬,靳洪珍,张金声,陆道培. 干扰素a－2b治疗慢性髓性白血病[J]. 北京大学学报(医学版), 1994, 0(3) |
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| 作者姓名： | 傅剑锋 王德炳 单福香．江滨 张景云 张丽丽 赵军 毕加敬 靳洪珍 张金声 陆道培 |
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| 作者单位： | 北京医科大学血液病研究所 |
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| 摘 要： | 应用干扰素ａ－２ｂ治疗慢性髓性白血病２５例，重点探讨（１）小剂量治疗是否有效；（２）疗效与慢性髓性白血病病期的关系；（３）能否诱导细胞遗传学或基因的缓解；（４）单用或联合用药疗效比较。结果提示，干扰素ａ－２ｂ应用於慢性期有较理想的疗效、完全血液学缓解达２６．３％，部分血液学缓解７３．７％，加速期疗效较差，与羟基脲或马利兰配合用药可提高疗效，我们近期观察２５例中，无一例达完全缓解，有待进一步观察和探索合理的治疗方案。
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| 关 键 词： | 干扰素，慢性髓性白血病，血液学缓解，完全缓解 |
CLINICAL STUDIES OF INTERFERON a-2b IN PATIENTS WITH CHRONIC MYELOGENOUS I EUKEMIA |
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| Institute of Haematology Fu Jianfeng,et al. CLINICAL STUDIES OF INTERFERON a-2b IN PATIENTS WITH CHRONIC MYELOGENOUS I EUKEMIA[J]. Journal of Peking University. Health sciences, 1994, 0(3) |
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| Authors: | Institute of Haematology Fu Jianfeng et al |
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| Abstract: | his paper reported the therapeutic results of treatment of interferon a-2b in 25 cases of chronicmyelogenousleukemia. What discussed here were:(1)whether it is effective with low dose interferon therapy;2)the relationship between curatibe efficacy and duration of disease;(3)Whether interferon can indubce remission of cytogenetic and genetic ; (4 )compare the results of single agent chemotherapy with that of combination therapy.It was indicated that more satisfactory results could be obtained in chronic phase of CML with interferon. Complete hematologic remission rate was 26.3%, Partial hema-tyoiogic remission rate was 73.7%. Curative efficacy was poor in accelerated phase,it can be impro-ved when combined with hydroxyurea or busulfan . Because no patient obtained complete remlssion in our 25 cases ,a appropriate regimen is curreqtly under observation and investigation |
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| Keywords: | Interferon Chronic myelogenous leukemia Hematologyic remission Complete rem i-ssion |
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