癫痫发作的神经电生理特征

癫痫是以反复发作的阵发性神经性或行为表现为特征的脑功能失调,其原因是大群神经元的不正常同步性过度放电。癫痫的发病率占总人群的0.5%-2%[1],癫痫不是单一疾病,原因不一,反映了后天与遗传的多因素病症。多数癫痫综合症可以划分为两种基本类别[2]:部分性(partial)和全身性(generalized)。部分性发作发生在大脑的局部区域内,所以又称为局灶性癫痫,而全身性发作则出现在整个前脑(至少在EEG水平)[2]。有关癫痫发作的可能机制已被广泛研究,从神经元、突触、神经元组成的网络,到解剖、生理、生化、遗传和分子生物学,都积累了大量的文献[2],…

The electrophysiologic character of epileptic seizure

Epilepsy is a family of neurological disorders that are common and harmful to human's health. The etiologies of epilepsy and the clinical manifestations of seizures are complex and various. To elucidate the mechanisms underlying seizure generation, lots of researches in the anatomy, physiology, biochemistry, genetic and molecular biology of epilepsy have been done over many years. However, no single hypothesis provides a unifying framework within which all kinds of epilepsy can be included so far. In fact, the electrophysiologic essence of epileptic seizure is abnormal excess discharges of neurons. On the standpoint of electrophysiology, the reasons of abnormal discharges of neurons are of common character: depolarizing currents with long durations and high amplitudes on cell levels, which is closely related to slow waves with high amplitudes on EEG levels. This can make us understand the mechanism of epileptic seizures better, and is helpful for well control and therapy of seizures.