| 黄芪及缬沙坦对肾型高血压大鼠心脏血管紧张素转化酶2表达的影响 |
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| 引用本文： | 任红梅,余静,张缤.黄芪及缬沙坦对肾型高血压大鼠心脏血管紧张素转化酶2表达的影响[J].临床心血管病杂志,2010,26(3). |
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| 作者姓名： | 任红梅 余静 张缤 |
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| 作者单位： | 1. 宁夏回族自治区人民医院心内科,银川,750024
2. 兰州大学第二附属医院心内科 |
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| 摘 要： | 目的:探讨两肾一夹高血压大鼠心脏血管紧张素转化酶2(Angiotensin-Converting Enzyme2,ACE2)mRNA、蛋白表达水平及甘肃定西黄芪(Astragalus in Gansu Dingxi,Ast)和缬沙坦(Valsartan,Val)对其表达的影响。方法:健康雄性Wistar大鼠,体重180~200g,构建两肾一夹KIC高血压模型。术后随机分为5组,假手术组;②2KIC组;③Val+2KIC组;④Ast+2KIC组(低剂量);⑤Ast+2KIC组(高剂量)。在观察期末,分别测定各组大鼠体重、心脏湿重,计算出心脏重量/体重;光镜下观察心肌结构的变化;RT-PCR检测各组心肌组织ACE2mRNA,免疫组化测定其蛋白表达。结果:与假手术组比较,2KIC组、Val+2KIC、Ast+2KIC组(低剂量)、Ast+2KIC组(高剂量)心脏重量/体重均升高(P<0.05);②与假手术组比较,2KIC组ACE2mRNA、蛋白表达显著减少;与2KIC组比较,Val+2KIC组及Ast+2KIC组(高剂量)经8周治疗后,ACE2mRNA、蛋白表达量增加(P<0.05)。结论:高血压大鼠心脏ACE2m...
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| 关 键 词： | 高血压 黄芪 大鼠 血管紧张素转化酶2 缬沙坦 |
Effects of radix astragali on expression of angiotensin-converting enzyme 2 in heart of 2 kidney 1 chip hypertensive rats |
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| REN Hongmei,YU Jing,ZHANG Bin.Effects of radix astragali on expression of angiotensin-converting enzyme 2 in heart of 2 kidney 1 chip hypertensive rats[J].Journal of Clinical Cardiology,2010,26(3). |
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| Authors: | REN Hongmei YU Jing ZHANG Bin |
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| Institution: | 1Department of Cardiology/a>;People's Hospital of Ningxia Hui Autonomous Region/a>;Yingchuan/a>;750024/a>;China/a>;2Department of Cardiology/a>;The Second Hospital of Lanzhou University |
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| Abstract: | Objective:To investigate the expression of ACE2 MRNA and angiotensin-converting enzyme 2(ACE2)in the heart of 2kic hypertensive rats and the effects of(Valsartan,Val)and Astragalus in Gansu Dingxi(Ast).Methods:Healthy male wistar rats,weight 180-200 g,are randomly divided into 5 groups after operation.There are 9 rats in each group.Sham operated group were served as control group,2KIC group,2KIC+val group,2KIC+Ast group(low dose)and 2KIC+Ast group(high dose).The following parameters were examined:body weigh... |
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| Keywords: | 2 KICrat angiotensin-converting enzyme2 renal angiotensinII valsartan astragalus |
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