丹参多酚酸盐合用环磷腺苷葡胺对冠心病PCI术后血液流变,hs-CRP及NT-proBNP的影响

目的:观察丹参多酚酸盐合用环磷腺苷葡胺对冠心病心绞痛经皮冠状动脉介入治疗术(percutaneous coronary intervention,PCI)后患者症状、心功能及血液流变学的影响。方法:本院78例冠心病心绞痛PCI术后患者随机分为两组,对照组(常规术后治疗)33例和治疗组(在常规治疗上加用丹参多酚酸盐200 mg,环磷腺苷葡胺120 mg静滴,qd)45例,治疗时间为术前24 h至术后2周,观察两组临床疗效、心功能改变及血液流变学变化。结果:症状改善,两组治疗后全血高切黏度、低切黏度、血浆黏度、D-二聚体与治疗前有统计学意义(P0.05);血清超敏C反应蛋白(hypersensitive C-reactive protein,hsCRP)水平两组存在差异,与治疗前比均有统计学意义(P0.05),血脑利钠钛前体(pro-brain natriuretic peptide,NT-pro BNP)水平两组存在差异,与治疗前比均有统计学意义(P0.05),且治疗组更明显,差异有统计学意义(P0.05)。结论:丹参多酚酸盐合用环磷腺苷葡胺在冠心病心绞痛PCI术后可改善血液流变,临床症状及心功能状况。

Effect of Salviae Miltiorrhizae Radix et Rhizoma Polyphenols Acid Salt Combined with Adenosine Cyclophosphate Meglumine on Hemorheology, hs-CRP and NT-proBNP of Post-PCI Patients With Coronary Heart Disease

Objective: To observe the effect of Salviae Miltiorrhizae Radix et Rhizoma polyphenols acid salt combined with adenosine cyclophosphate meglumine on symptoms, cardiac functions and hemorrheology of patients with coronary heart disease after the percutaneous coronary Intervention (PCI). Method: Totally seventy-eight post-PCI cases of coronary heart disease were randomly divided into 2 groups:the control group (routine postoperative therapy, 33 cases) and the treatment group (conventional therapy combined with intravenous dropping of 200 mg Salviae Miltiorrhizae Radix et Rhizoma phenolic acid salt and 120 mg adenosine cyclophosphate meglumine, qd, 45 cases). The treatment time lasted from 24 h before the surgery to 2 weeks after the surgery. The clinical efficacy and changes in heart function and hemorrheology were observed. Result: The symptoms were relieved. After the treatment, the two groups showed statistical significance in whole blood high shear viscosity, low shear viscosity, plasma viscosity, D-dimer, hypersensitive C-reactive protein (hs-CRP) and pro-brain natriuretic peptide (NT-proBNP) compared with values before the treatment (P<0.05),and the treatment group is more obvious, with statistical significance in differences (P<0.05). Conclusion: Salviae Miltiorrhizae Radix et Rhizoma polyphenols acid salt combined with adenosine cyclophosphate meglumine can improve hemorrheology, clinical symptoms and cardiac function among of post-PCI patients with coronary heart disease.