| 离子色谱法同时测定丹参注射剂中6种无机阴离子 |
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| 引用本文： | 张元,李伟青,周伟娥,任志芹,冯雪松,周昱,张峰. 离子色谱法同时测定丹参注射剂中6种无机阴离子[J]. 中国实验方剂学杂志, 2015, 21(17): 24-27 |
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| 作者姓名： | 张元 李伟青 周伟娥 任志芹 冯雪松 周昱 张峰 |
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| 作者单位： | 中国检验检疫科学研究院 食品安全研究所, 北京 100176;中国医科大学 药学院, 沈阳 110013,中国检验检疫科学研究院 食品安全研究所, 北京 100176,中国检验检疫科学研究院 食品安全研究所, 北京 100176,中国检验检疫科学研究院 食品安全研究所, 北京 100176,中国医科大学 药学院, 沈阳 110013,中国医科大学 药学院, 沈阳 110013,中国检验检疫科学研究院 食品安全研究所, 北京 100176 |
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| 基金项目： | 国家重大科学仪器设备开发专项(2012YQ14000806);国家质检总局科技计划专项(2014Ik084);质检公益性行业科研专项(201410088-02);辽宁省科学技术厅自然科学基金项目(201202252) |
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| 摘 要： | 目的:建立了能够同时测定丹参注射剂中6种无机阴离子(氟离子、甲酸根、氯离子、亚硝酸根、溴离子和硝酸根)含量的离子色谱方法。方法:采用IC-2100离子色谱,Ion Pac AS11-HC阴离子色谱柱(4 mm×250 mm),KOH梯度淋洗,电导检测器检测6种无机阴离子含量。结果:6种无机阴离子基本达到基线分离,线性关系良好,相关系数分别在0.999 5~0.999 9,平均回收率分别在90.1%~106.5%。结论:所建立的方法快速、准确、简便、实用,可用于丹参注射剂中6种无机阴离子的含量测定和质量控制。
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| 关 键 词： | 离子色谱 丹参注射剂 无机阴离子 超声波提取法 |
| 收稿时间： | 2015-03-24 |
Simultaneous Determination of 6 Inorganic Anions in Danshen Injection by Ion Chromatography |
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| ZHANG Yuan,LI Wei-qing,ZHOU Wei-e,REN Zhi-qin,FENG Xue-song,ZHOU Yu and ZHANG Feng. Simultaneous Determination of 6 Inorganic Anions in Danshen Injection by Ion Chromatography[J]. China Journal of Experimental Traditional Medical Formulae, 2015, 21(17): 24-27 |
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| Authors: | ZHANG Yuan LI Wei-qing ZHOU Wei-e REN Zhi-qin FENG Xue-song ZHOU Yu ZHANG Feng |
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| Affiliation: | Institute of Food Safety, Chinese Academy of Inspection and Quarantine, Beijing 100176, China;School of Pharmacy, China Medical University, Shenyang 110013, China,Institute of Food Safety, Chinese Academy of Inspection and Quarantine, Beijing 100176, China,Institute of Food Safety, Chinese Academy of Inspection and Quarantine, Beijing 100176, China,Institute of Food Safety, Chinese Academy of Inspection and Quarantine, Beijing 100176, China,School of Pharmacy, China Medical University, Shenyang 110013, China,School of Pharmacy, China Medical University, Shenyang 110013, China and Institute of Food Safety, Chinese Academy of Inspection and Quarantine, Beijing 100176, China |
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| Abstract: | Objective: An ion chromatography method for simultaneous determination of six inorganic anions(fluoride, formic, chloride, nitrite, bromide and nitrate) in Danshen injection was established. Method: Six inorganic anions were determined by anion exchange column Ion Pac AS11-HC(4 mm×250 mm), eluted by gradient hydroxide potassium. Result: Good resolution can be achieved among the above mentioned six inorganic anions.Their linear correlations over the investigated concentration were in the range of 0.999 5-0.999 9, while the average recoveries ranged from 90.1% to 106.5%, respectively. Conclusion: The ion chromatography method is fast, accurate, simple, reliable and applicable for the determination and quality control of inorganic anions in Danshen injection. |
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| Keywords: | ion chromatography Danshen injection inorganic anion ultrasonic extraction |
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