维生素K对尾悬吊大鼠骨代谢的影响

目的 探讨维生素K对模拟失重大鼠骨质的影响，为失重骨丢失的防护提供实验依据。方法 将SD雄性大鼠分为3组，自由对照组（FAC），悬吊对照组（SC），维生素K悬吊组（SVK）（50mg/kg weight/d)，每组9只。每天灌胃给药，实验期为21d。观察维生素K对尾悬吊大鼠血清骨钙素（BGP）、骨生物力学、矿盐含量、一氧化氮（NO）含量及碱性碱酸酶（ALP）活性含量的影响。结果 与SC比较，SVK血清总BGP和结合型BGP，股骨和胫骨矿盐含量，股骨生物力学，胫骨ALP活性含量均显著增加；股骨干NO含量明显减少。结论 维生素K可改善尾悬吊大鼠的骨代谢和骨结构，减少骨丢失，提高骨生物力学性能，降低骨折危险度。

Effects of Vitamin K on Bone Metabolism in Tail-suspended Rats.

Objective To study the effects of vitamin K on bone metabolize in simulated weightlessness rats. Method Male SD rats were divided into three groups(n=9):the free active control (FAC),the tail suspended control (SC), and the tail suspended group treated with vitamin K (SVK) (50 mg/kg weight/d). The experiment lasted for 3 weeks. Bone biomechanical properties, bone mineral contents(BMC) and bone biochemical markers of bone metabolism were determined. Result Compared with SC, total and bound bone gla protein(BGP) of serum , BMC of the femur and tibia, femoral mechanical properties, ALP activity of tibia all increased significantly; while NO content of femoral trunk decreased significantly. Conclusion Vitamin K improved the bone metabolism and bone structure, decreased bone loss,increased bone biomechanical properties, decreased catagmatic fatalness. It proved that vitamin K prevented bone loss of simulated weightlessness rats.