|
|||||
|
|
DECREASED BIOACTIVITY OF CIRCULATING PROLACTIN IN PATIENTS WITH RHEUMATOID ARTHRITIS |
|
| Authors: | BERCZI, I. COSBY, H. HUNTER, T. BARAGAR, F. McNEILLY, A. S. FRIESEN, H. G. |
| Affiliation: | 1Departments of Immunology Department of Medicine, Faculty of Medicine, University of Manitoba Winnipeg, Manitoba, Canada, R3E0W3 2Departments of Physiology Department of Medicine, Faculty of Medicine, University of Manitoba Winnipeg, Manitoba, Canada, R3E0W3 3Departments of Rheumatic Disease Unit. Department of Medicine, Faculty of Medicine, University of Manitoba Winnipeg, Manitoba, Canada, R3E0W3 |
| Abstract: | Growth hormone and prolactin (PRL) were measured by radio-immunoassayin sera of 36 patients with rheumatoid arthritis (24 femalesand 12 males) and of 50 normal blood donors (25 males and 25females). The bioactivity of PRL was also determined for bothgroups, using the Nb2 rat lymphoma proliferation assay. Althoughno significant difference was found between serum PRL valuesof patients and controls when determined by radio-immunoassay,the bioactivity of PRL was significantly decreased in patientssera, when compared to values obtained in age and sex-matchedcontrols. This decreased PRL bioactivity could not be attributedto drug treatments administered to the patients examined. KEY WORDS: Rheumatoid arthritis, Prolactin bioactivity, Prolactin immunoreactivity * Present address: Shaughnessy Hospital, 4500 Oak St., Vancouver,B.C., Canada. Present address: MRC Reproductive Biology Unit, 37 ChalmersSt., Edinburgh EH3 9EW, UK. |
| Keywords: | |
| 本文献已被 Oxford 等数据库收录！ | |