| Azone预处理对丹参素经皮渗透的影响 |
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| 引用本文： | 刘重芳,吴洁,戴居云,张钰泉.Azone预处理对丹参素经皮渗透的影响[J].中成药,2000,22(4):251-252. |
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| 作者姓名： | 刘重芳 吴洁 戴居云 张钰泉 |
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| 作者单位： | 上海中医药大学,上海,200032 |
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| 基金项目： | 国家自然科学青年基金资助项目,编号 39700191 |
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| 摘 要： | 目的：了解Ａｚｏｎｅ对丹参浸膏中丹参素的透皮促渗作用。方法：采用离体裸鼠皮肤，应用Ｆｒａｎｚ扩散池进行体外渗透量、渗透系数。结果：Ａｚｏｎｅ不同用量，不同时间的预处理均有明显促渗作用。渗透方程均为零级模式。结论：促渗剂预处理是一种较好的促渗方法。
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| 关 键 词： | 预处理 Azone 丹参素 经皮渗透 |
| 文章编号： | 1001-1528(2000)04-0251-02 |
| 修稿时间： | 1999年11月1日 |
Effect of Pretreatment with Azone on Percutaneous Permeability of Salvianolic Acid A |
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| LIU Chong-fang,WU Jie,DAI Ju-yun,ZHANG Yu-quan.Effect of Pretreatment with Azone on Percutaneous Permeability of Salvianolic Acid A[J].Chinese Traditional Patent Medicine,2000,22(4):251-252. |
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| Authors: | LIU Chong-fang WU Jie DAI Ju-yun ZHANG Yu-quan |
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| Abstract: | Objective: To observe the effects of Azone on the percutaneous permeability of Salvianolic acid A in Radix Salviae Miltiorrhizae. Methods: Drug permeation in vitro test was performed on excised hairless mice skin in Franz diffusion cell. The cumulative permeable amounts and coefficient of Salvianolic acid A were evaluated. Results: Pretreatments with Azone in different concentration and time increased the percutaneous transport of Salvianolic acid A. For all cases the drug penetration process could be described by zero order kinetic mechanism. Conclusion: It indicates that pretreatment with penetration enhancers is an effective method of enhancing permeability of drugs. |
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| Keywords: | Pretreatment Azone Salvianolic acid A Penetratic rate |
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