| 大鼠角膜碱烧伤后角膜淋巴管生成及VEGF-C和VEG-FR-3的表达 |
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| 引用本文： | 郑彩慧,朱学军,张声,周琳瑛,徐国兴. 大鼠角膜碱烧伤后角膜淋巴管生成及VEGF-C和VEG-FR-3的表达[J]. 国际眼科杂志, 2010, 10(12): 2246-2249. DOI: 10.3969/j.issn.1672-5123.2010.12.005 |
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| 作者姓名： | 郑彩慧 朱学军 张声 周琳瑛 徐国兴 |
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| 作者单位： | 福建医科大学附属漳州市医院漳州眼科中心,中国福建省漳州市,363000;福建医科大学附属第一医院眼科,中国福建省福州市,350007;福建医科大学附属第一医院病理科,中国福建省福州市,350007;福建医科大学电镜教研室,中国福建省福州市,350004 |
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| 摘 要： | 目的:研究大鼠角膜碱烧伤后角膜淋巴管生成及VEGF-C和VEGFR-3的表达。方法:制作角膜碱烧伤模型,应用免疫组化方法检测正常角膜及烧伤后1,3,5,7,14,21,28d角膜组织中VEGF-C和VEGFR-3的表达,免疫组化LYVE-1(淋巴管内皮特异标记物)染色观察角膜中淋巴管生成情况,电镜观察烧伤后14d角膜新生淋巴管状况。结果:角膜碱烧伤后,VEGF-C和VEGFR-3的表达明显升高,烧伤后3d,角膜中出现淋巴管。结论:角膜碱烧伤后新生淋巴管生成伴VEGF-C和VEGFR-3高表达。
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| 关 键 词： | 淋巴管 淋巴管内皮细胞透明质酸受体-1 血管内皮生长因子受体3 血管内皮生长因子C 角膜 碱烧伤 大鼠 |
Expression of VEGF-C,VEGFR-3 and lymphangion genesis in rat cornea after alkali burn |
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| Cai-Hui Zheng,Xue-Jun Zhu,Sheng Zhang,Lin-Ying Zhou and Guo-Xing Xu. Expression of VEGF-C,VEGFR-3 and lymphangion genesis in rat cornea after alkali burn[J]. International Eye Science, 2010, 10(12): 2246-2249. DOI: 10.3969/j.issn.1672-5123.2010.12.005 |
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| Authors: | Cai-Hui Zheng Xue-Jun Zhu Sheng Zhang Lin-Ying Zhou Guo-Xing Xu |
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| Affiliation: | Cai-Hui Zheng1,Xue-Jun Zhu2,Sheng Zhang3,Lin-Ying Zhou4,Guo-Xing Xu21Zhangzhou Eye Center,Zhangzhou Affiliated Hospital of Fujian Medical University,Zhangzhou 363000,Fujian Province,China,2Department of Ophthalmology,3Department of Pathology,the First Affiliated Hospital of Fujian Medical University,Fuzhou 350007,4Department of Electron Microscope,Fujian Medical University,Fuzhou 350004 |
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| Abstract: | AIM:To investigate the expression of VEGF-C,VEGFR-3 and lymphangion genesis in rat cornea after alkali burn. ·METHODS:The rat alkali burnt corneal model were made. The expression of VEGF-C,VEGFR-3 and lymphangion genesis labeled with LYVE-1 in rat cornea were detected by immunohistochemical assay at day 0 and day 1,3,5,7,14,21,28 after burn. In addition,the ultrastructure of lymphangion genesis in rat cornea was observed by electron microscope. ·RESULTS:The expression of VEGF-C and VEGFR-3 in rat cornea were increased after alkali burn. LYVE-1 were detected in rat cornea 3 days after alkali burn.·CONCLUSION:There are some new lymphangion genesis in rat cornea after alkali burn. And meanwhile,the expression of VEGF-C and VEGFR-3 in rat cornea was significantly increased. |
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| Keywords: | lymphatic vessels LYVE-1 VEGFR-3 VEGF-C cornea alkali burn rat |
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