急性脑梗死患者超敏C反应蛋白动态变化与预后关系的研究

目的探讨超敏C反应蛋白(hs-CRP)在急性脑梗死(ACI)发病过程中的变化及其与预后的关系。方法采用免疫比浊法动态检测82例急性脑梗死患者及20名正常对照者的hs-CRP变化,分析hs-CRP与梗死面积大小,病情和预后的相关性。结果ACI患者hs-CRP水平与病情及预后关系密切,其中大梗死组hs-CRP升高,持续时间长,神经功能缺损程度越重,预后越差;与中、小梗死组比较,差异有统计学意义(P<0.01)。结论ACI患者hs-CRP水平可作为判断病情及预后的客观指标,hs-CRP越高,持续时间越长,预后越差。

Relationship between the kinetic changes of high-sensitive C-reactive protein level and prognosis in patients with acute cerebral infarction

Objective To investigate the association between the kinetic changes of high-sensitive C-reactive protein level and prognosis during the progression of acute cerebral infarction .Methods High-sensitive C-reactive protein levels of 82 patients with acute cerebral infarction and 20 healthy volunteers served as a control group were tested with immunoturbidimetric assay and were analyzed whether to correlate with severity and outcome after acute cerebral infarction. Results There was the significant correlation between high-sensitive C-reactive protein levels and severity, prognosis in patients with acute cerebral infarction. High-sensitive C-reactive protein levels in larger infarction group was higher and lasted longer than that in middle and smaller infarction groups, the difference was statistically significant (P<0.01). High levels of high-sensitive C-reactive protein in larger infarction group indicated more severe neurologic functional impairment and worse prognosis.Conclusion High-sensitive C-reactive protein is a significant risk factor for severity and prognosis in patients with cerebral infarction. If high-sensitive C-reactive protein levels are high and last long,the patients with cerebral infarction have unfavourable prognosis.