产前筛查对出生缺陷的预防

目的分析马鞍山市区4893例孕中期先天愚型儿产前筛查情况。方法对孕中期（14—21周）4893例孕妇进行甲胎蛋白（AFP）和游离一HCG（free—B—HCG）的血清生化指标检测,经特殊软件计算,对可能影响检测结果的部分因素,如年龄、体重,孕周等加以分析校正,分析孕妇怀有出生缺陷的风险。结果筛查例中期孕妇4893例,筛查21-3体高危个体184例,阳性率为3.76%,比全国统计结果略高。21-3体阳性率3.76%,18-3体18例,阳性率0.37%,NTD高风险48例,阳性率0.98%,与全国统计结果相近。结论在中孕期间检测AFP和B一HCG筛查DS及神经管畸形胎儿,对避免新生儿的出生缺陷起到较好的预防作用,同时为马鞍山地区人群提供了自己的检测软件系统。

Prenatal screening program for the prevention of the birth defects

Objective Analyzes the Mnanshan urban district to the pregnant interm-ediate stage Down＇ s syndrome sieves looks up the situations.Methods To is pregnant the intermediate stage（14-21 week） 4893 cases of the pregnant woman carries on armor embryo protein（AFP）and the dissociation β-hCG（Free β-hCG） the blood serum biochemistry target examination,after the special software computation,affects the examination.Result to the possibility the partial factors,like the age,the body weight,and pregnant the week and so on to analyze adjust,analyze the pregnant woman to harbor the DS son＇s risk.Finally Sieves looks up 4893 example interme-diate stage pregnant woman.the high—risk individual 184 examples,the masculine gender rate is 3.76%,is higher than the national statistics result.Conclusion Exam ines AFP in the gestation period and Free β-hCG sieves looks up the DS embryo,to avoids the Tang birth good screening function,also the Maanshan urban district should have this crowd＇s examination appraisal software system.