hsCRP与原发性高血压心肌纤维化相关性分析

目的 观察原发性高血压患者血清高教C反应蛋白(hsCRP)与心肌声学密度的变化情况,探讨hsCRP与高血压心肌纤维化的关系.方法 将入选对象84例,分为健康对照组30名,原发性高血压无左心室肥厚组(NLVH) 28例及原发性高血压左心室肥厚组(LVH)26例.应用超声心动图测量声学密度各项值,采用免疫胶乳比浊法测定hsCRP.结果 NLVH组hsCRP与对照组相比有增高趋势,但无统计学意义(P＞0.05),LVH组hsCRP与NLVH组相比显著性升高(P＜0.01).NLVH组与对照组相比,矫正的声学强度(CAI1、CAI2)背向散射积分周期变化值(CVIB1、CVIB2)无统计学意义(P＞0.05),LVH组与NLVH组相比,CAI1、CAI2值显著性升高(P＜0.01),CVIB1、CVIB2值显著性降低(P＜0.01).hsCRP与CAI1、CAI2呈直线正相关(P＜0,01),hsCRP与CVIB1、CVIB2呈直线负相关(P＜0.01).结论 hsCRP与原发性高血压心肌纤维化之间有明显相关性.

Correlation of hs-CRP and Mocardial Fibrosis in Essential Hypertension

Objective To observe the changes of plasma high-sensitivity C-reactive protein(hsCRP) and myocardial acoustic densitometry in patients with essential hypertension(EH),and investigate the relationship between high-sensitivity C-reactive protein(hsCRP) and myocardial fibrosis.Methods All patients were divided into 3 groups:Normal control group(n=30),left ventricular hypertrophy group(LVH group,n=26),and patients without left ventricular hypertrophy group(NLVH group,n=28).Acoustic densitometry was examined by echocardiography.The levels of plasma hsCRP were analyzed by immune latex turbidimetry.Results Compared with normal group,there was an increased tendency of hsCRP in NLVH group(P>0.05).The levels of hsCRP were significantly higher in LVH groups than that in NLVH group(P<0.01).Compared with normal group,there was no significant difference in calibrated acoustic intensity(CAI) 1,CAI2,cyclic variation of integrated backscatter(CVIB) 1,and CVIB2 in NLVH group(P>0.05).Compared with NLVH group,CAI1 and CAI2 were significantly increased(P<0.01),CVIB and CVIB2 were lower in LVH group(P<0.01).The hsCRP was positively correlated with CAI1 and CAI2(P<0.01),and hsCRP was negatively correlated with CVIB1 and CVIB2(P<0.01).Conclusion The levels of hsCRP are correlated with myocardial fibrosis in EH patients.