Analysis of four patients with advanced gastric cancer undergoing gastrectomy after pre-operative combination chemotherapy using docetaxel, cisplatin and S-1 |
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Authors: | Nagase Takeshi Kanai Toshio Nakagawa Motohito Kumamoto Yusuke Imai Syun Wada Osamu Honda Tomo Hoshino Go Atsukawa Kazuhiro Sakaguchi Takashi Shiba Tadahiko Nonaka Takashi Imajyo Kento Ogawa Yuji |
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Institution: | Dept. of Surgery, Hiratsuka City Hospital. |
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Abstract: | We analyzed the clinical efficacy of pre-operative combination chemotherapy using docetaxel, cisplatin and S-1 for advanced gastric cancer. Four patients were enrolled and staging laparoscopy was performed. Patients received intravenous docetaxel and cisplatin (35 mg/m2) on day 1 and 15, and oral S-1 80 mg/m2 on day 1-14 every 4 weeks. Two patients received two courses of chemotherapy and two patients received three courses of chemotherapy. Neutropenia of more than grade 3 was found in 3 cases. All cases were PR on preoperative imaging. Curative operation was performed on three cases. Histological anti-tumor effect was judged to be grade 2 in 1 case and grade 1a in 3 cases. In the postoperative period, all patients received S-1-based adjuvant chemotherapy. The combination chemotherapy using docetaxel, cisplatin and S-1 plus operation was a candidate for the standard treatment strategy for advanced gastric cancer. |
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