血清胆红素和血脂的综合指数与冠心病的关系研究

目的探讨血清胆红素与血脂的综合指数与冠心病(CHD)的关系.方法将80名行冠状动脉造影术的患者分为2组:CHD组与对照组(冠状动脉正常).测定血清总胆红素水平(TBIL),总胆固醇(TC),高密度脂蛋白胆固醇(HDL-C),低密度脂蛋白胆固醇(LDL-C),计算出其综合指数:LDL-C/(HDL-C TBIL)和TC/(HDL-C TBIL),分析其与CHD之间的关系.结果CHD患者血清TBIL水平明显低于非冠心病患者(P＜0.05).CHD患者总胆固醇(TC),低密度脂蛋白胆固醇(LDL-C),LDL-C/(HDL-C TBIL)比值,TC/(HDL-C TBIL)比值水平明显高于冠状动脉正常组(P＜0.05).进行Logistic回归分析,TC,LDL-C,LDL-C/(HDL-C TBIL),TC/(HDL-C TBIL)可引入Logistic回归模型,它们为CHD的危险因素.结论CHD的发生与TBIL的降低有一定的相关性,综合考虑血脂、血清胆红素与血脂的综合指数有助于CHD的诊断.

A Study on Relation Between Various lipid lipoprotein and Bilirubin Combinations and Coronary Heart Disease

Objective To study the relation between composite index of serum bilirubin and serum lipid variables and coronary heart disease. Methods A total of 80 patients who had undergone coronary angiography entered the study. They were dividied into two groups by their results of coronary angiography:1.CHD 2.Normal. We tested serum bilirubin(TBIL),cholesterol(TC),low density lipoprotein cholesterol(LDL-C),high density lipoprotein cholesterol(HDL-C),TC/(HDL-C bilirubin),LDL-C/(HDL-C bilirubin). Their relation were investigated. Results Serum bilirubin of CHD group is lower than normal group,Cholesterol(TC),low density lipoprotein cholesterol(LDL-C),TC/(HDL-C bilirubin),LDL-C/(HDL-C bilirubin) of CHD group is higher than normal group (P <0.05). Each of these bilirubin-containing ratio is risk factor of CHD. Conclusion We think over various lipid lipoprotein and TC/(HDL-C bilirubin) ratio, LDL-C/(HDL-C bilirubin) ratio together will improve the diagnosis of CHD.