脑星形细胞瘤中TIP30、VEGF和CD34的表达及其相关性研究 |
| |
引用本文: | 赵玉红,张杰英,崔爱荣,马毓梅,王恒树,李月红,吴文新,张祥宏.脑星形细胞瘤中TIP30、VEGF和CD34的表达及其相关性研究[J].肿瘤研究与临床,2009,21(1):444-446,449. |
| |
作者姓名: | 赵玉红 张杰英 崔爱荣 马毓梅 王恒树 李月红 吴文新 张祥宏 |
| |
作者单位: | 河北医科大学第二医院病理科,石家庄,050000; |
| |
摘 要: | Objective To investigate the expression and relationship of TIP30(HIV-1 Tat interactive protein 2), vascular endothelial growth factor (VEGF) and MVD (detected by CD34) in the angiogenesis of human brain astrocytomas. Methods Expression of TIP30, VEGF and CD34 in 19 cases of normal brain tissue and 71 cases of astrocytoma were immunohistochemically examined with Elivision plus two-step method. Results The positive expression of TIP30 could be seen in cytoplasm of neuroglial cells and neurons of 19 normal brain tissues. The positive expression rate of TIP30 in 71 cases of astrocytoma was 33.80 % (24/ 71). The positive expression rate of TIP30 in astrocytoma of different grades was 52 % for grade Ⅱ, 34.78 % for grade Ⅲ and 13.04 % for grade Ⅳ. The positive expression rate of TIP30 in high grade (Ⅲ+Ⅳ) of astrocytoma was found significantly lower than that in low grade(Ⅱ) (χ2=5.71, P <0.05); The expression of VEGF and MVD detected by CD34 in astrocytomas were higher than that in normal brain tissue and increased as the tumor grade increased; In astrocytoma, the negtive correlation was found between the expression of TIP30 and VEGF (r=-0.428, P<0.05); no correlation was found between TIP30 and MVD(r=-0.065, P 0.05); the positive correlation was found between VEGF and MVD(r=0.684, P<0.01). Conclusion The positive expression rate of TIP30 in normal brain tissue is significantly higher than that in astrocytoma. The positive expression rate of TIP30 significantly decreases as the pathological grade of the astrocytoma increases; The expression of TIP30 and VEGF is negatively correlated in astrocytoma.
|
关 键 词: | 星形细胞瘤 血管内皮生长因子 抗原 CD34 免疫组织化学 |
Expression and significance of TIP30, VEGF and CD34 in brain astrocytoma |
| |
Abstract: | |
| |
Keywords: | TIP30AstrocytomaTIP30VEGFAntigens CD34Immunohistochemistry |
|
|