音乐刺激激活人脑情感系统的fMRI研究

目的：利用fMRI技术，对音乐欣赏相关脑功能区进行定位，并初步探讨音乐情感反应和音乐治疗的可能神经机制。方法：采用组块设计模式，对30名非音乐专业志愿者进行被动聆听音阶、轻音乐和恐怖音乐（各3段）实验。应用SPM99软件对实验结果进行组分析，获得平均激活图。结果：轻音乐和恐怖音乐可激活大脑与情感加工相关的脑区．前者主要包括双侧前额皮层外侧部（左侧为著）、左侧眶额皮层、扣带回前部、左侧岛叶前部、右侧丘脑和左侧豆状核；后者主要包括双侧前额皮层外侧部（右侧为著）、双侧眶额皮层、双侧额内回和扣带回前部和双侧杏仁复合体，结论：音乐可有效激活人脑与情感加工相关脑区；大脑对喜悦和恐惧情感具有不同（或部分交叉）的神经加工网络．其中．轻音乐引起的正性情感加工可能是音乐治疗的部分神经基础。

The Activation of Human Affective System During Passive Music Listening: A Preliminary fMRI Study

Objective: To localize the functional areas related to music processing with fMRI,and to discuss the possible neural mechanism underlying emotion experience and music therapy.Methods: Thirty healthy non-musicians underwent fMRI study.Experimental tasks included listening passively to instrumental pieces of scale,pleasant classic music and scary music(3 pieces each),which were given in block design.Conjunction analysis was performed with SPM99 to render the mean functional images.Results: Both the pleasant music and the scary music activated the neural substrates underlying affective processing;the former mainly included bilateral lateral prefrontal cortex(left advantage),the left orbitofrontal cortex,the anterior cingulate cortex,the left anterior part of insula,the right thalamus and the left lenticula;the later mainly included bilateral lateral prefrontal cortex(right advantage),bilateral orbitofrontal cortex,bilateral medial frontal gyri,bilateral anterior cingulate cortex and bilateral amygdaloid complex.Conclusion: Passively listening to pleasant and scary music could strongly activate distinct emotion processing substrates,and the positive emotion processing system activation during pleasant music listening may be one of the neural mechanisms of music therapy.