| 藻酸双酯钠对巨噬细胞6-酮-前列腺素F_(1α)和血栓烷B_2合成的影响 |
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| 引用本文： | 肖殿模,王小鲁,张俊宝,陈华粹,车璟,李桂玲. 藻酸双酯钠对巨噬细胞6-酮-前列腺素F_(1α)和血栓烷B_2合成的影响[J]. 中国新药与临床杂志, 1992, 0(4) |
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| 作者姓名： | 肖殿模 王小鲁 张俊宝 陈华粹 车璟 李桂玲 |
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| 作者单位： | 中国医学科学院基础医学研究所 北京100005(肖殿模，王小鲁，张俊宝，陈华粹)，青岛第三制药厂 青岛266022(车璟)，青岛第三制药厂 青岛266022(李桂玲) |
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| 基金项目： | 国家自然科学基金资助,No 3870662 |
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| 摘 要： | 小鼠腹腔巨噬细胞培养基中加入藻酸双酯钠,浓度大于10μg/mL时,培养基内6-酮-前列腺素F_(1α)和血栓烷B_2含量显著增加(P<0.001),并具剂量依赖性特点。藻酸双酯钠刺激前列腺素合成的作用可能是其心血管作用的机制之一。
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| 关 键 词： | 粘多糖类 6-酮-前列腺素F_(1α) 血栓素B_2 巨噬细胞 |
Effect of polysaccharide sulfate on 6-keto-prostaglan-din F_(1a) and thromboxane B_2 in macrophages in vitro |
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| XIAO Dian-Mo,WANG Xiao-Lu,ZHANG Jun-Bao,CHEN Hua-Cui. Effect of polysaccharide sulfate on 6-keto-prostaglan-din F_(1a) and thromboxane B_2 in macrophages in vitro[J]. Chinese Journal of New Drugs and Clinical Remedies, 1992, 0(4) |
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| Authors: | XIAO Dian-Mo WANG Xiao-Lu ZHANG Jun-Bao CHEN Hua-Cui |
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| Abstract: | Effect of polysaccharide sulfate (PSS) on synthesis of protaglandin in the mouse resident peritoneal macrophages was studied. After the cells were treated with PSS>10ug/mL for 6 h, the levels of 6-keto-prostaglandin F 1 alpha (G-keto-PGF1a) and thromboxane B2 (TXB2) in the media were increased (P<0.001). The stimulation of synthesis of 6-keto-PGF1a and TXB2 by PSS was concentration-dependent. It is suggested that stimulation of prostaglandin synthesis by PSS might be partially responsible for its cardiovascular efficacy. |
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| Keywords: | mucopolysaccharides 6-keto-prostaglandin F1 alpha thromboxaue B2 macrophagcs |
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