结缔组织在针刺力学信号转导中的作用和研究进展

非特异性结缔组织(筋膜结缔组织)在针刺力学信号转导中具有重要的作用。针刺产生的机械应力对于非特异性结缔组织中的成纤维细胞、细胞骨架等在形态学、组织化学、生物化学等方面均有一定的影响,包括成纤维细胞的变形、细胞骨架的重塑、生化物质的释放等。本文结合目前细胞生物学、影像学和生理学对于这种影响的最新研究进行归纳,认为明确牵拉应力在结缔组织的转导途径及对机体的影响对于揭示针灸疗效的机制具有重要的意义。

Advances in the Study on the Role of Connective Tissue in the Mechanical Signal Transduction of Acupuncture

Non-specific connective tissue (fascia connective tissue) plays an important role In the mechanical signal transduction of acupuncture. Acupuncture needle manipulation-induced mechanical stress has a certain effect on the fibroblasts and cytoskeleton in the nonspecific connective tissue (including loose connective tissue and fat tissue) in morphology, histochemistry and biochemistry. For example, acupuncture-needle manipulation can make the fibroblast deformed, the cytoskeleton remodeled and result in the release of biochemical materials from the connective tissue. The present review summarizes new results of studies on the effect of acupuncture needle manipulation from cytobiology, imageology and physiology; and holds that making clear the transduction pathways of acupuncture mechanical stress signals in the connective tissue and its impact on the organism possesses an important significance in revealing the mechanism of acupuncture underlying clinical therapeutic effects.