MMP-2／MMP-9在乳腺癌组织中的表达及其与肿瘤浸润转移的关系

BACKGROUND: Matrix melloproteinases play a pivotal role in tumor invasion and metastasis, but little is known about the correlation between their expression and the prognosis of breast cancer.OBJECTIVE: To investigate the expression of matrix melloproteinases-2 and matrix melloproteinases-9 (MMP-2/MMP-9) and the distributive form of CollV (type IV collagen)in the tissues of breast carcinoma, and find out their relationship with tumor invasion and metastasis so as to disclose the mechanism of the tumor invasion and metastasis of breast carcinoma.SETTING and PARTICIPANTS: Eighty-two filed wax masses of samples from the removed breast carcinoma and 30 filed wax masses of samples from the control group were collected at random from the First Affiliated Hospital of Fujiatt Medical University.MAIN OUTCOME MEASURE: The expression of MMP-2, MMP-9 and the distributive form of CollV in the tissues of breast carcinoma and in the tissues without breast carcinoma, and the correlation of the results with clinieopathological tumor parameters.METHODS: Tissues were obtained from 82 patients with breast carcinoma and 30 without breast carcinoma. The expression of MMP-2, MMP-9 and the distributive form of ColIV were examined, and their correlation with clinicopathological tumor parameters was explored.RESULTS: ① The positive incidences of MMP-2 and MMP-9 expression in 82 cases of breast carcinoma were 52 % (43/82) and 54% (44/82) respectively, The distributive form of encapsulated CollV was 15% (12/82),and the distributive form of decomposed CollVwas 85% (70/82), which were different apparently from those of the control group, ② The expressions of MMP-2/MMP-9 were related to the distribution form of ColIV( P &;lt; 0.05).③The expression of MMP-9 was related with the metastasis of the axillary lymph node (X^2 =8, 1899, P &;lt; 0, 05), and the expressions of MMP-2 was not related with the metastasis of the axillary lymph node(X^2 = 3. 3590, P&;gt;0.05),CONCLUSION: MMP-2, MMP-9 play a pivotal role in tumor invasion and metastasis. The result is suggested that detection of MMP-2/MMP-9 helps to judge the malignant severity of breast carcinoma and its biological behavior.