牛黄降压片中冰片含量及樟脑残留量的测定

目的：建立牛黄降压片中冰片含量及樟脑残留量的测定方法。方法：气相色谱法，采用色谱柱19091N-213和INNOWAX石英毛细管色谱柱（30 m×0.32 mm×0.5μm），柱温130℃，FID为检测器，无水乙醇为提取溶剂。结果：冰片质量浓度在0.0975～3.8984 mg/mL 范围内与峰面积呈良好的线性关系（r=0.9999），平均加样回收率（n=6）为101.0%，相对标准偏差（relative standard deviation，RSD）为0.71%；樟脑浓度在1.041～20.82μg/μL范围内与峰面积呈现良好的线性关系（r=0.9995），平均加样回收率（n=6）为100.4%， RSD为1.4%。结论：气相色谱法简便、灵敏、专属性强，适用于牛黄降压片的质量控制。

Determination of borneol content and camphor residue in Niuhuang Jiangya tablet

Objectiv e： To establish the determination method of borneol content and camphor residue in Niuhuang Jiangya tablet. Methods： Gas chromatography（GC）,The samples were separated on a quartz capillary column of 19091N-213 IN-NOWAX （30 m×0.32 mm×0.5μm）;column temperature was 130 ℃;FID was used and alcohol was selected as extraction a-gent. Results：The calibration curve of borneol showed good linearity in the range of 0.097 5-3.898 4 mg/mL（r=0.999 9）;the average recovery（n=6） was 101.0% with RSD of 0.71%. The calibration curve of camphor showed good linearity in the range of 1.041-20.82 μg/mL（r=0.999 5）; the average recovery（n=6） was 100.4% with RSD of 1.4%. Conclusion： GC is simple, sensitive with high specificity, and can be used in the quality control of Niuhuang Jiangya tablet.