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Association of cognitive performance with interleukin-6 receptor Asp358Ala polymorphism in healthy adults |
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| Authors: | Daimei Sasayama Hiroaki Hori Toshiya Teraishi Kotaro Hattori Miho Ota Junko Matsuo Yumiko Kawamoto Yukiko Kinoshita Naoji Amano Hiroshi Kunugi |
| Institution: | (1) Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4-1-1, Ogawahigashi, Kodaira Tokyo, 187-8502, Japan;(2) Department of Psychiatry, Shinshu University School of Medicine, Matsumoto 390-8621, Japan;(3) Core Research of Evolutional Science and Technology (CREST), Japan Science and Technology Agency (JST), Tokyo 102-0075, Japan |
| Abstract: | Wechsler adult intelligence scale-revised was performed in 576 healthy adults to examine whether a functional polymorphism (Asp358Ala) of the IL-6 receptor (IL-6R) gene is associated with cognitive performance. Verbal intelligence quotient in Asp homozygotes was significantly higher compared to Ala carriers (P = 0.005). Compared to Ala carriers, Asp homozygotes performed better in the verbal subtests requiring long-term memory stores. Elevated IL-6 and soluble IL-6R levels in Ala carriers may have negative impact on acquiring verbal cognitive ability requiring long-term memory. |
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