系统性红斑狼疮合并心力衰竭患者心肌肌钙蛋白I水平的监测及临床意义

目的探讨心肌肌钙蛋白I（cTnI）变化对诊断系统性红斑狼疮（SLE）心脏损伤的临床意义及其与病情活动的关系。方法应用Beckman Coulter Access Immunoassay System 2对SLE合并心力衰竭患者、SLE无心力衰竭患者和健康人血清cTnI水平进行测定，用SLE活动指数积分评价SLE患者病情活动情况。结果SLE心力衰竭组血清cTnI增高，与无心力衰竭组的差异有统计学意义；无心力衰竭组血清cTnI与健康对照组的差异无统计学意义。血清cTnI的变化与SLE病情活动指数无相关性；其变化与病程有相关性。结论SLE合并心力衰竭时有心肌损伤存在，提示预后较差，治疗时应加强保护心肌。

Monitoring of serum cardiac troponin-I level and its clinical significance in SLE patients combined with heart failure

Objective To explore the clinical significance of cardiac troponin I （cTnI） measurement in the diagnosis of cardiac injury complicated by systemic lupus erythematosus （SLE） and its relationship with disease activi ty. Methods Beckman Coulter Access Immunoassay System 2 was applied to measuring cTnI in SLE patients with heart failure （HF group）, SLE patients without heart failure （non-HF group） and healthy people （healthy control group）. The SLE activity was assessed with systemic lupus erythematosus disease active index （SLEDAI）. Results Serum level of cTnI was significantly higher in HF group than that in non-HF group; there was no statistical difference in serum level between non HF group and healthy control group. There was no correlation between serum cTnI change and SLE disease activity index, whereas serum cTnI change was associated with the course of disease. Conclusion Myocardial damage in SLE combined with heart failure is an indication of poor prognosis. Myocardial protection should be strengened in clinical therapy.