| 失血性休克致鼠心肌线粒体内膜的损伤 |
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| 引用本文： | 朱善宏 缪明永. 失血性休克致鼠心肌线粒体内膜的损伤[J]. 第二军医大学学报, 1992, 13(3): 212-215 |
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| 作者姓名： | 朱善宏 缪明永 |
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| 作者单位： | 第二军医大学训练部生物化学教研室 200433(朱善宏，缪明永，陈克明)，第二军医大学训练部生物化学教研室 200433(石汉平) |
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| 摘 要： |
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| 关 键 词： | 休克 失血性 线粒体 呼吸链 损伤 |
Hemorrhagic Shock-induced Damage in the Inner Membrane of Rat Myocardial Mitochondria |
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| Zhu Shanhong,Miao Mingyong,Chen Kerning,Shi Hangping. Hemorrhagic Shock-induced Damage in the Inner Membrane of Rat Myocardial Mitochondria[J]. Former Academic Journal of Second Military Medical University, 1992, 13(3): 212-215 |
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| Authors: | Zhu Shanhong Miao Mingyong Chen Kerning Shi Hangping |
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| Abstract: | The alterations in electron transport were studied in the myocardial mitochondria of rats with hemorrhagjc shock. Hemorrhagic shock model was induced by a modified Wigger procedure. Mitochondria were obtained by differential centrifugation. Succinate-, and NADH-respiratory chains were assayed by polarographically and spectrophotometrically in isolated myocardial mitochondria. The results showed that hemorrhagic shock led to progressive decrease in the enzymatic activities of two respiratory chains. The activities of Succinate-Co. Q reductase, Succinate-Cyt. C reductase, NADH-Co. Q reductase, NADH-Cty. C reductase and cytochrome oxidase were remarkably lower in shock 3 h group than those in the shamoperated. This implies that there is not only low-flow hypoxia, but inability to utilizer oxygen in the myocardial mitochondria |
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| Keywords: | shock hemorrhagic mitochondria respiratory chain animal rats |
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