The relative contribution of direct and indirect antigen recognition pathways to the alloresponse and graft rejection depends upon the nature of the transplant |
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| Authors: | Illigens Ben M Yamada Akira Fedoseyeva Eugenia V Anosova Natalie Boisgerault Florence Valujskikh Anna Heeger Peter S Sayegh Mohamed H Boehm Bernhard Benichou Gilles |
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| Institution: | Cellular and Molecular Immunology Laboratory, Schepens Eye Research Institute and Department of Ophthalmology, Harvard Medical School, 20 Staniford Street, Boston, MA 02114, USA. |
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| Abstract: | In this study, we measured direct and indirect T-cell alloresponses mediated by CD4(+) and CD8(+) T cells in three mouse transplantation models: skin, cornea, and retina. We show that the contribution of direct and indirect antigen recognition pathways to the alloresponse to fully allogeneic grafts varies depending upon the nature of the tissue/organ transplanted. The implications of this finding for understanding the cellular mechanisms by which rejection is mediated in different transplant models are discussed. |
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