| 阿尔茨海默病与雌激素受体α基因多态性的相关性探讨 |
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| 引用本文： | 李红民,陈盛强,柳息洪,王延平,黄绍宽. 阿尔茨海默病与雌激素受体α基因多态性的相关性探讨[J]. 解剖学研究, 2004, 26(2): 109-111 |
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| 作者姓名： | 李红民 陈盛强 柳息洪 王延平 黄绍宽 |
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| 作者单位： | 广州市白云区人民医院,广州,510630;广州医学院.广州,510182;广州市老人院 |
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| 摘 要： | 目的 探讨雌激素受体α基因突变在阿尔茨海默病(AD)发病中的意义。方法 用PCR扩增66例AD患者及143例对照者的激素受体α基因突变点,经限制性内切酶消化后行凝胶电泳确定其基因型。结果 雌激素受体α基因各种基因型频率在患者组与正常对照组之间的差异无显著性。结论 就目前的调查的例数来看,激素受体α基因突变可能不足以构成阿尔茨海默病的独立遗传性危险因子。
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| 关 键 词： | 老年性痴呆 雌激素受体α 基因多态性 |
| 修稿时间： | 2003-12-25 |
Relationship between estrogen receptor gene polymorphism and Alzheimer desease |
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| Li Hongmin,Chen Shengqiang,Liu Xihong,WangYanping,Huang Shaokuan. Baiyun District Hospital,Guangzhou China. Relationship between estrogen receptor gene polymorphism and Alzheimer desease[J]. Anatomy Research, 2004, 26(2): 109-111 |
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| Authors: | Li Hongmin Chen Shengqiang Liu Xihong WangYanping Huang Shaokuan. Baiyun District Hospital Guangzhou China |
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| Affiliation: | Li Hongmin,Chen Shengqiang,Liu Xihong,WangYanping,Huang Shaokuan. Baiyun District Hospital,Guangzhou 510020 China |
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| Abstract: | Objective To investigate the relationship between estrogen receptor gene polymorphism and Alzheimer disease (AD). Methods By polymerase chain reaction-restriction fragment length polymorphism( PCR-RFLP) , ER gene polymorphism was analyzed in 66 AD patients and 143 control individuals, and the distribution of ER genotype was compared in AD group and control group. Results there were no siganificant differences in the frequenceies of estrogen receptor mutations between the patients and contral groups. Conclusion Estrogen receptor may not be independent risk factors for Alzheimer disease in Chinese. |
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| Keywords: | Alzheimer disease Estrogen receptor Gene polymorphism |
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