| 用腹水代替卵巢癌组织检测mdr1可行性研究 |
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| 引用本文： | 白符,张云艳,杨宏伟.用腹水代替卵巢癌组织检测mdr1可行性研究[J].哈尔滨医科大学学报,2001,35(5):363-364. |
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| 作者姓名： | 白符 张云艳 杨宏伟 |
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| 作者单位： | 哈尔滨医科大学附属第三医院妇科 |
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| 摘 要： | 目的 探讨初治晚期卵巢患者癌组织及腹水细胞中多药耐药基因（mdr1)表达及其相关性。方法 应用RT-PCR技术对34例卵巢癌患者的癌组织及腹水癌细胞的mdr1表达进行检测。结果 卵巢癌组织mdr1阳性表达率为20.6%，腹水癌细胞mdr1阳性表达率为26.5%，经统计学处理二者间无显著性差异。结论 卵巢癌组织与腹水癌细胞mdr1表达具有相关性。腹水mdr1表达情况可间接反映卵巢癌组织细胞对化疗药物耐受程度。
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| 关 键 词： | 卵巢肿瘤 腹水癌细胞 多药耐药基因 逆转录－聚合酶链反应 |
| 文章编号： | 1000-1905(2001)05-0363-02 |
| 修稿时间： | 2000年9月4日 |
Viability of mdr1 detection by using ascites cancerou s cells rather than neoplastic tissue in ovarian carcinoma |
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| BAI Fu,ZHANG Yun yan,YANG Hong wei.Viability of mdr1 detection by using ascites cancerou s cells rather than neoplastic tissue in ovarian carcinoma[J].Journal of Harbin Medical University,2001,35(5):363-364. |
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| Authors: | BAI Fu ZHANG Yun yan YANG Hong wei |
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| Abstract: | Objective To explore the correlation of mdr 1 expression between neoplastic tissues and ascites cancerous cells(ACC) in advanced ovarian carcinoma.Methods The mdr 1 expression of neoplastic tissues and ascites cancerous cells were detected by RT PCR in 34 ovarian carcinomas.Results The positive expression of mdr 1 was 20.6% in neoplastic tissues and 26.5% in ACC.The difference had no statistical significance.Conclusion The expression of mdr 1 in ACC can tell indirectly the multidrug resistance degree of ovarian neoplastic tissues. |
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| Keywords: | ovarian neoplasms ascites cancerous cells mdr 1 RT PCR |
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