羟基脲相关多发疣状皮肤角化合并皮肤鳞状细胞癌一例

报告1例长期使用羟基脲引起的多发疣状皮肤角化并发皮肤鳞癌。患者女，55岁，以双手足多发黄色至黑褐色疣状角化丘疹、斑块，左手掌溃疡性肿块为主要表现。患者有骨髓纤维化病史8年，长期服用羟基脲。左手掌肿块经组织病理证实为皮肤鳞癌。给予左前臂截肢术，其余皮损外用咪喹莫特治疗。

A case of hydroxycarbamide-associated multiple verrucous keratosis complicated by cutaneous squamous cell carcinoma

We report a case of hydroxyurea-associated multiple verrucous keratoses and squamous cell carcinoma of the skin. A 55-year-old female patient presented with multiple yellowish to brownish verrucous keratotic papules, plaques on both hands and feet, ulcerative mass on left palm. She had a history of bone marrow fibrosis that was well controlled by hydroxyurea therapy for 8 years. Histopathology of ulcerative mass on left palm showed cutaneous squamous cell carcinoma. The patient subsequently underwent left forearm amputation, and the remainder of the lesions were treated by imiquimod.