| 乙醇对大鼠不同组织细胞膜钠泵活性的影响 |
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| 引用本文： | 张世联,王桂兰.乙醇对大鼠不同组织细胞膜钠泵活性的影响[J].中国药理学通报,1992,8(4):306-309. |
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| 作者姓名： | 张世联 王桂兰 |
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| 作者单位： | 河北省医学科学院实验医学研究所生化室 石家庄050021
(张世联，符云峰，刘建功)，河北医学院卫生系毒理室 石家庄050017
(王桂兰)，河北省医学科学院实验医学研究所生化室 石家庄050021(王薇) |
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| 摘 要： | 观察了灌喂大鼠乙醇(790mg·kg~(-1))30、60和90d对心、肝、脑和肾组织细胞膜Na~+,K~+—ATP酶活性的影响,并对60和90d时红细胞进行了Rb转运测定及动力学分析。发现30d时心肌组织Na~+,K~+—ATP酶活性减低;60d时肝组织Na~+,K~+—ATP酶活性减低,但红细胞~(86)Rb主动转运增高,其动力学分析类似非竞争抑制型;肾和脑组织的钠泵活性均无明显改变。结果表明乙醇首先影响心肌组织,其次是肝组织钠泵活性,且对不同细胞膜钠泵活性的影响各异。90d时未见乙醇对酶的影响。
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| 关 键 词： | 乙醇 细胞膜 Na~+ K~+—ATP酶 Tb跨膜转运 |
Effect of ethanol on Na~+, K~- - ATPase of different cell memberanes |
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| ZHANG Shi -Lian. FU Yun-Feng,WANG Gui -Lian et al.Effect of ethanol on Na~+, K~- - ATPase of different cell memberanes[J].Chinese Pharmacological Bulletin,1992,8(4):306-309. |
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| Authors: | ZHANG Shi -Lian FU Yun-Feng WANG Gui -Lian |
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| Institution: | Dept. of Biochemstry. Hebei Academy of Medical Science. Shi jiazhuang 050021 |
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| Abstract: | The activity of Na+, K+-ATPasc from heart. liver, kidney, brain and crythrocytes of SD rats after perfusing ethanol (790mg · kg-1 · d-1) 30. 60. 90 consecutive days were studied. The activity of Na+, K+-ATPase from cardiac sarcolemmal microsomes of the 30d rats was decreased ; the activity of enzyme of liver decreased was found in the 60d rats.but the Kb active transport in erythrocytes was increased significantly; we did not find any change of these membranes by comparing with control group in the 90d rats, the results showed that the ethanol has a varied influensces on different cell membranes. |
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| Keywords: | Ethanol Cell mcmbnanc Na~+ K~+-ATPasc 86~Rb transport |
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