87例中药制剂的不良反应报告分析

目的了解中药制剂不良反应发生的特点,为临床安全用药提供参考。方法对2005年至2010年87例中药制剂药品不良反应报告进行回顾性分析。结果87例药品不良反应涉及18种中药制剂,其中13种中药注射剂;有67例(77.01%)发生在用药后30 min内;由静脉滴注给药75例,占86.21%;临床表现以皮肤及其附件损害最多,占48.28%。全身性损害及循环系统损害较严重的有呼吸困难、气紧、胸闷、白细胞减少等。结论应加强药品不良反应监测报告工作,合理使用中药制剂,保证患者用药安全。

Report Analysis on 87 Cases of Adverse Drug Reactions Induced by Traditional Chinese Medicines

Objective To understand the occurrence characteristics of adverse drug reactions（ADR） of traditional Chinese medicines to provide reference for clinical medication safety.Methods Eighty-seven cases of Chinese medicine ADR reports from 2005 to 2010 were analyzed retrospectively.Results Eighty-seven cases of ADR were involved 18 kinds of Chinese medicine preparations,including 13 kinds of Chinese medicine injections,accounting for 72.22%;67 cases（77.01%） occurred within 30 min after administration;the administration route of intravenous drip was in 75 cases（86.21%）;the clinical manifestations were mainly damage of skin and its appendages,accounting for 48.28%,followed by systemic damage and circulatory system damage,and more severe events including breathing difficulties,tightness in breathing,chest tightness and leukopenia.Conclusion Should strengthen the report work of ADR monitoring and rationally use the traditional Chinese medicine preparations to ensure patient＇s medication.