肿瘤细胞及辐照对近交系KM-HL小鼠影响的研究

目的 观察KM-HL鼠对肿瘤细胞的易感性;对¹³⁷Cs-γ射线致免疫功能下降的研究,为KM-HL鼠作为实验用鼠提供理论依据。方法 给KM-HL小鼠接上S₁₈₀、U₁₄和H₂₂等肿瘤,观察其生长情况;使KM-HL受到¹³⁷Cs-γ线6.5Gy照射后,致免疫功能下降,观察血液、造血系统、脾系数、胸腺系数等免疫指标。结果 KM-HL小鼠接种S₁₈₀、U₁₄和H₂₂的液体瘤细胞或实体瘤均生长较好;KM-HL小鼠受到照射后各项生理指标与对照组比有所下降并有统计学意义(P<0.01)。结论 近交系KM-HL小鼠可作为肿瘤药物筛选和免疫功能药物筛选的实验用鼠。

Study on the Influence of Tumor Cell and Radiation on KH-HL Mice

Objective To observe the susceptibility to tumor cell of KH-HL mice and study the descent of immune function by ¹³⁷Cs source γ rays to provide theoretical foundations for KM-HL mice use as experimental mice.Methods The mice sarcoma (S₁₈₀), cervical cancer (U₁₄), and liver cancer (H₂₂)are transplanted on KM-HL mice and the growth of mice bearing tumor is observed, its immune function of KH-HL mice descends when irradiate with ¹³⁷Cs source γ rays at 6.5Gy, Some immunization indexes such as blood, hematopoietic system, spleen index and thymus index are examined.Results Both the liquid tumor cell and the solid tumor of sarcoma (S₁₈₀), cervical cancer (U₁₄), and liver cancer (H₂₂)transplants on KM-HL mice grow well.After the irradiation, all of the physiological indexes of KM-HL mice descend comparing with the control group, with statistical significance (P<0.01).Conclusion The inbred line KM-HL mice can be used as experimental model mice in the screening of antitumor and immunological function drugs.