| 愈骨胶囊镇痛和抗炎活性的实验研究 |
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| 引用本文： | 王琴,邢茂,易美彤,敖利. 愈骨胶囊镇痛和抗炎活性的实验研究[J]. 中国药房, 2011, 0(27): 2506-2508 |
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| 作者姓名： | 王琴 邢茂 易美彤 敖利 |
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| 作者单位： | 重庆市中医院药物研究部;第三军医大学第二附属医院药剂科; |
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| 基金项目： | 重庆市卫生局中医药科技项目(2009-2-113) |
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| 摘 要： | 目的:研究愈骨胶囊对小鼠的镇痛、抗炎作用。方法:实验分6组,即正常、模型、阿司匹林和愈骨胶囊高、中、低剂量组。采用热板法(实验分5组,无正常组)和醋酸扭体法,观察愈骨胶囊的镇痛作用;采用二甲苯致小鼠耳肿胀模型和醋酸致小鼠腹腔毛细血管通透性增加模型,观察愈骨胶囊的抗炎作用。结果:与给药前比较,给药后180min,高、中剂量愈骨胶囊可显著延长小鼠痛阈值(P<0.05);与正常组比较,模型组小鼠扭体次数显著增加(P<0.01),与模型组比较,高、中、低剂量愈骨胶囊显著降低小鼠扭体次数(P<0.01,P<0.05);与正常组比较,模型组小鼠耳肿胀度显著增加(P<0.01),与模型组比较,高、中、低剂量愈骨胶囊组小鼠的耳肿胀度显著降低(P<0.01,P<0.05);与正常组比较,模型组小鼠腹腔毛细血管通透性增加(P<0.01),与模型组比较,高、中剂量愈骨胶囊可显著降低小鼠毛细血管通透性(P<0.05)。结论:愈骨胶囊具有镇痛、抗炎作用,但与剂量无明显相关性。
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| 关 键 词： | 愈骨胶囊 抗炎作用 镇痛作用 |
Study on Analgesic and Anti-inflammatory Activities of Yugu Capsules |
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| WANG Qin,YI Mei-tong,AO Li XING Mao. Study on Analgesic and Anti-inflammatory Activities of Yugu Capsules[J]. China Pharmacy, 2011, 0(27): 2506-2508 |
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| Authors: | WANG Qin YI Mei-tong AO Li XING Mao |
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| Affiliation: | WANG Qin,YI Mei-tong,AO Li(Dept.of Drug Research,Chongqing Hospital of Traditional Chinese Medicine,Chongqing 400020,China) XING Mao(Dept.of Pharmacy,The Second Affiliated Hospital of Third Military Medical University,Chongqing 400037,China) |
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| Abstract: | OBJECTIVE:To explore the anti-inflammatory and analgesic effect of Yugu capsules in mice.METHODS:Experimental mice were divided into 6 groups,normal group,model group,aspirin group and Yugu high-dose,medium-dose and low-dose groups.The trials of hot plate test were divided into 5 groups without normal group.The analgesic effect of Yugu capsules was investigated through hot plate test and acetic acid writhing test.The anti-inflammatory effects were observed through xylene-induced ear swelling and acetic acid... |
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| Keywords: | Yugu capsules Anti-inflammatory effect Analgesic effect |
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