| 多西紫杉醇、5-氟尿嘧啶联合顺铂对晚期胃癌的疗效及安全性评价 |
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| 引用本文： | 张爱虹,李长福,冯小东,侯宇澄.多西紫杉醇、5-氟尿嘧啶联合顺铂对晚期胃癌的疗效及安全性评价[J].中国药房,2011(26):2474-2476. |
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| 作者姓名： | 张爱虹 李长福 冯小东 侯宇澄 |
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| 作者单位： | 哈尔滨医科大学附属肿瘤医院药剂科;哈尔滨医科大学附属肿瘤医院外科; |
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| 摘 要： | 目的:评价多西紫杉醇、5-氟尿嘧啶联合顺铂对晚期胃癌的疗效及安全性。方法:58例晚期胃癌患者随机分为对照组与治疗组,每组29例。对照组给予5-氟尿嘧啶+顺铂;治疗组给予多西紫杉醇+5-氟尿嘧啶+顺铂。以21d为1个周期,治疗2个周期后评价疗效及安全性。结果:对照组总有效率为37.93%,治疗组总有效率为55.17%,2组比较差异有统计学意义(P<0.05);2组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:多西紫杉醇、5-氟尿嘧啶联合顺铂治疗晚期胃癌效果显著,不增加不良反应,安全性高,值得临床推广应用。
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| 关 键 词： | 多西紫杉醇 5-氟尿嘧啶 顺铂 晚期胃癌 |
Efficacy and Safety Evaluation of Docetaxel,5-fluorouracil and Cisplatin in the Treatment of Advanced Gastric Cancer |
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| ZHANG Ai-hong,FENG Xiao-dong,HOU Yu-chengLI Chang-fu.Efficacy and Safety Evaluation of Docetaxel,5-fluorouracil and Cisplatin in the Treatment of Advanced Gastric Cancer[J].China Pharmacy,2011(26):2474-2476. |
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| Authors: | ZHANG Ai-hong FENG Xiao-dong HOU Yu-chengLI Chang-fu |
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| Institution: | ZHANG Ai-hong,FENG Xiao-dong,HOU Yu-cheng(Dept.of Pharmacy,The Affiliated Tumor Hospital of Harbin Medical University,Harbin 150040,China)LI Chang-fu(Dept. of Surgery,China) |
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| Abstract: | OBJECTIVE:To evaluate the clinical efficacy and safety of docetaxel and 5-fluorouracil combined with cisplatin in the treatment of advanced gastric cancer. METHODS: 58 cases of advanced gastric cancer were randomly divided into treatment group and control group, 29 cases in each group. Control group were given 5-fluorouracil and cisplatin, and treatment group were given 5-fluorouracil, cisplatin and docetaxel. A cycle lasted for 21 days. After two cycles, the clinical efficacy and safety were evaluated. RES... |
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| Keywords: | Docetaxel 5-fluorouracil Cisplatin Advanced gastric cancer |
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