银杏叶提取物对糖尿病肾病抗氧化应激及血液流变作用的影响

目的：观察银杏叶提取物对糖尿病肾病（DN）患者血清氧化应激及血液流变学指标的影响。方法：将DN患者按自愿原则分为银杏叶提取物（美怡欣注射液）治疗组和对照组。观察两组治疗前后血清超氧化物歧化酶（SOD）、谷光甘肽过氧化酶（GSH—Px）、丙二醛（MDA）及血液流变学指标的变化。结果：治疗前两组SOD、GSH—Px、MDA和血液流变学指标无明显差异。银杏叶提取物治疗后SOD、GSH—Px较对照组明显升高，MDA明显降低（P〈0．01）；尿蛋白定量较对照组明显下降（P〈0．01）；低切全血黏度、红细胞压积、红细胞聚集指数和血小板聚集率较对照组和同组治疗前显著下降（P〈0．01），而高切全血黏度和血浆黏度下降不明显；红细胞变形性显著增高（P〈0．01）。结论：DN患者细胞抗氧化能力明显降低；银杏叶提取物通过提高抗氧化应激能力及改善血液流变性，减少蛋白尿对肾脏起保护作用。

Effect of ginkgo leaf extract on oxidative stress and haemodynamics in diabetic nephropathy patients

To investigate the effect of ginkgo leaf extract on oxidative stress and haemodynamics of diabetic nephropathy ( DN). METHODS: The patients of DN were divided into ginkgo leaf extract treatment group and control group. The changes of serum super-oxide dismutase ( SOD ) , glutathione peroxidase ( GSH-Px) , malondialdehyde ( MDA) and hemorheology in-dexes were observed. RESULTS: Before treatment, serum SOD, GSH-Px, MDA and hemorheology indexes had no significant difference between ginkgo leaf extract treatment group and control group. After treatment, the serum levels of T-SOD and GSH-Px were increased; the level of MDA, hemorheology indexes,erythrocyte aggregation index and platelet aggregation rate were de-creased significantly in ginkgo leaf extract treatment group compared with those in control group ( P < 0.01). CONCLUSION: The antioxidant ability of cells were deceased in DN. Ginkgo leaf extract could protect the renal function by increasing the activities of SOD and GSH-Px, improving the hemorheology, de-creasing the albuminuria.