| 水芹总酚酸治疗大鼠非酒精性脂肪肝的实验研究 |
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| 引用本文： | 胡克章,年国侠,杨坤,黄正明.水芹总酚酸治疗大鼠非酒精性脂肪肝的实验研究[J].解放军药学学报,2009,25(1):29-33. |
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| 作者姓名： | 胡克章 年国侠 杨坤 黄正明 |
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| 作者单位： | 1. 军事医学科学院,北京,100850;解放军第302医,院药学部药理研究室,北京,100039
2. 解放军第302医,院药学部药理研究室,北京,100039 |
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| 基金项目： | 军队科研基金面上课题 |
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| 摘 要： | 目的观察水芹总酚酸total phenolic acid extracted from Oenanthe javanica（B1）DC（OJTPA）]，OJTPA对高糖高脂肪饲料诱导的大鼠非酒精性脂肪肝的治疗作用。方法用高糖高脂肪饲料喂养大鼠30d建立非酒精性脂肪肝模型，停止造模，分组并给药，连续给药4周，检测血清和肝脏中生化指标，做肝脏组织病理学检查。结果非酒精性脂肪肝大鼠经OJTPA治疗后，血清中TG含量和ALT活性显著降低（P〈0．05）；肝组织中TG、TC、MDA、FFA含量减少，SOD活力增加（P〈0．05）；肝细胞脂肪肝程度明显减轻，肝细胞坏死程度减轻。结论水芹总酚酸能降低高糖高脂肪饮食诱导的非酒精性脂肪肝大鼠血液和肝脏中TG含量，对非酒精性脂肪肝有治疗作用，其作用机制可能与水芹总酚酸的抗氧化作用，减轻脂质过氧化引起的肝脏损伤，降低肝脏脂肪沉积有关。
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| 关 键 词： | 水芹总酚酸 非酒精性脂肪肝 治疗 实验研究 |
The Study of Therapeutical Effect of Total Phenolic Acid Extracted from Oenanthe Javanica (Bl) DC on Non-alcoholic Fatty Liver in Rats |
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| HU Ke-Zhang,NIAN Guo-Xia,YANG Kun,HUANG Zheng-Ming.The Study of Therapeutical Effect of Total Phenolic Acid Extracted from Oenanthe Javanica (Bl) DC on Non-alcoholic Fatty Liver in Rats[J].Pharmaceutical Journal of Chinese People's Liberation Army,2009,25(1):29-33. |
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| Authors: | HU Ke-Zhang NIAN Guo-Xia YANG Kun HUANG Zheng-Ming |
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| Institution: | 1.Academy of Military Medical Sciences, Beijing 100850 China; 2.Department of Pharmacy, Hospital 302 of PLA, Beijing 100039 China) |
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| Abstract: | Aim To observe the therapeutical effect of total phenolic acid extracted from Oenanthe javanica(Bl)DC(OJTPA)on the non-alcoholic fatty liver.Methods A model of the non-alcoholic fatty liver was constructed by feeding rats with high glucose and fatty diet for 30days.The rats were then fed with normal diet,randomly divided into groups and given intragastric administration.The biochemical indicators in blood serum and hepatic tissue were detected.Hepatic histological observation was performed after four weeks.... |
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| Keywords: | OJTPA non-alcoholic fatty liver therapy study |
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