Polymorphisms in GSTM1, GSTT1 and CYP1A1 and risk of pancreatic adenocarcinoma |
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| Authors: | Liu G Ghadirian P Vesprini D Hamel N Paradis A J Lal G Gallinger S Narod S A Foulkes W D |
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| Institution: | Centre for Research in Women's Health, Women's College Hospital, University of Toronto, Canada. |
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| Abstract: | A prospective study of 149 unselected incident cases of pancreatic adenocarcinoma and 146 ethnically-matched controls found no associations between GSTM1 (adjusted odds ratio (AOR) 1.14), GSTT1 (AOR: 1.19) and CYP1A1 (AOR: 1.08) polymorphisms and pancreatic cancer susceptibility. Smoking and drinking status did not affect results. These polymorphisms do not appear to be important gene modifiers in pancreatic cancer. |
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| Keywords: | pancreatic cancer genetic susceptibility cytochrome P450 glutathione S-transferase |
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