Parotid localized Castleman’s disease and HHV-8 infection: a case report |
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Authors: | Elisabetta Caselli Davide Padovani Roberto Di Carlo Enrico Grandi Monica Galvan Enzo Cassai Antonio Pastore |
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Institution: | (1) Section of Microbiology, Department of Experimental and Diagnostic Medicine, University of Ferrara, Ferrara, Italy;(2) Otorhinolaryngology Clinics, University of Ferrara, Ferrara, Italy;(3) Otorhinolaryngology Clinics, St. Anna Hospital, Ferrara, Italy;(4) Section of Anatomy Histology and Pathological Citology, University of Ferrara, Ferrara, Italy;(5) v.Marconi 55, 44012 Bondeno, Ferrara, Italy |
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Abstract: | Castleman’s disease (CD) is an unusual massive proliferation of lymphoid tissue distinct in two clinical forms, localized
and multicentric. The multicentric form has been related to human herpesvirus 8 (HHV-8), especially in HIV-infected patients,
whereas the localized form of CD is still unrelated to viral pathogens. We report a case of a HIV-negative 16-year-old male
referred to our hospital with a 12-month history of a painless swelling in his right parotid region. A parotidectomy was performed,
and histological analysis evidenced a localized CD. The search for HHV-8 revealed an active virus infection. The patient was
commenced on corticosteroid therapy and a follow-up was performed every 6 months. The patient was commenced on corticosteroid
therapy and there has been no recurrence after 24 months. The authors report a case of localized parotid CD in a patient with
evidence of an active HHV-8 infection. The results of this study does for the first time suggest an association between HHV-8
and localized CD in HIV-negative subjects. |
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Keywords: | Castleman’ s disease Parotid gland Human herpesvirus-8 Angiofollicular lymph node hyperplasia Viral infection |
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