Clinical value of 99mTc-HMPAO SPECT in depressed bipolar I patients |
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Authors: | Benabarre Antoni Vieta Eduard Martín Francisco Lomeña Francisco Martínez-Aràn Anabel Colom Francesc Corbella Barbara Gastó Cristóbal Valdés Manuel |
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Affiliation: | Institut Clínic de Psiquiatria i Psicologia, Bipolar Disorders Program, Hospital Clinic, University of Barcelona, IDIBAPS, C/Villarroel 170, 08036 Barcelona, Spain. 31555abh@comb.es |
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Abstract: | Regional cerebral blood flow was studied in 17 bipolar I depressed patients (DSM-IV criteria) with single photon emission computed tomography (SPECT). Visual analysis of images revealed no abnormality in eight patients and abnormal findings in nine patients. In the nine patients with abnormal findings, all showed regional decreases of the uptake of (99m)Tc-D,L-hexamethylpropylene amine oxime (HMPAO, four in the frontal region, two in the basal ganglia, and three in both the frontal region and the basal ganglia). The patients with visible SPECT abnormalities had significantly higher scores on the Hamilton Rating Scale for Depression (HDRS). |
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