Molecular forms of alpha-melanocyte-stimulating hormone in pheochromocytoma tissue |
| |
Authors: | Gardi J Khalil W K Vecsernyés M Gáspár L Szécsi M Julesz J |
| |
Institution: | Endocrine Unit, Albert Szent-Gy?rgyi Medical University, Szeged, Hungary. |
| |
Abstract: | The molecular forms of alpha-melanocyte-stimulating hormone (MSH) in pheochromocytoma tissues have been characterized using reversed-phase HPLC and radioimmunoassay. Six alpha-MSH-related peptides were detected. Three of the six peaks had elution times identical to those of synthetic desacetyl-alpha-MSH, alpha-MSH and diacetyl-alpha-MSH. The remaining three forms of the alpha-MSH-like immunoreactivity suggest a different processing of pro-opiomelanocortin in this tissue than in the intermediate lobe of the pituitary gland. Current results confirm that alpha-MSH are present in human pheochromocytoma and suggest that alpha-MSH has role in the pathophysiology of this tissue. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|