食管癌发生发展过程中环氧合酶-2蛋白表达的研究

目的 研究环氧合酶－2（Cox-2)蛋白在食管癌及癌前病变组织中的表达，探讨非类固醇抗炎药在食管癌高危人群中化学预防的可能性。方法 应用免疫组织化学方法检测120例食管癌（原位癌30例，鳞状细胞癌60例，腺癌30例）及其113例增生性病变（单纯增生29例，轻、中、重度不典型增生分别为31例、30例、23例）和27例正常食管黏膜鳞状上皮，以及3例Barrett食管组织中Cox-2蛋白的表达情况。结果 在正常食管黏膜上皮，单纯增生，轻、中、重度不典型增生，原位癌未发现有Cox-2蛋白表达；在6％（4／60）侵袭性鳞状细胞癌和70％（21／30）的食管腺癌中，Cox-2蛋白表达阳性。结论 Cox-2蛋白表达可能与食管腺癌的形成有关，而与鳞状细胞癌的发生发展无关。

A study on cyclooxygenase-2 protein expression in esophageal carcinoma and premalignant lesions

OBJECTIVE: To investigate cyclooxygenase-2(Cox-2) protein expression in esophageal cancer and precancerous lesions. METHODS: One hundred twenty biopsy specimens from patients with esophageal carcinoma, 113 from patients with esophageal premalignant lesions, 27 from individuals with normal esophageal mucosa and 3 from Barrett's esophagus were examined for Cox-2 protein expression by immunohistochemistry. RESULTS: Cox-2 protein was not observed in normal esophageal squamous and glandular epithelium, hyperplasia from mild to severe dysplasia lesions and carcinoma in situ. Positive Cox-2 expression was found in 4 of 60 specimens of invasive squamous-cell carcinomas, 21 of 30 specimens of esophageal adenocarcinomas and in 3 of 3 Barrett's esophageal tissues. CONCLUSION: The Cox-2 protein expression may be associated with the development of the esophageal adenocarcinomas but not esophageal squamous-cell carcinomas.