| 聚维酮碘膜剂的制备及质量控制 |
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| 引用本文： | 田睿,李勤耕,徐启贵.聚维酮碘膜剂的制备及质量控制[J].中国药房,2006,17(6):430-431. |
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| 作者姓名： | 田睿 李勤耕 徐启贵 |
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| 作者单位： | 重庆医科大学药学系,重庆市,400016 |
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| 摘 要： | 目的:研制高水溶性聚维酮碘膜剂,并建立其质量控制方法。方法:用聚维酮碘、甘油、蒸馏水和水溶性成膜材料聚乙稀醇05-88制备膜剂;以电位滴定法测定聚维酮碘含量,并分别考察成品在棕色和无色玻璃瓶中的稳定性。结果:制备的膜剂完整光洁、色泽均匀、厚度一致;平均加样回收率为99.03%(RSD=0.75%);膜剂在棕色玻璃瓶中60d内外观和含量均无明显变化,而在无色玻璃瓶中含量明显降低,外观也变为淡黄色。结论:本制剂的制备工艺简便,质量控制方法准确可靠。
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| 关 键 词： | 聚维酮碘膜剂 制备 质量控制 稳定性 |
| 文章编号： | 1001-0408(2006)06-0430-02 |
| 收稿时间： | 09 30 2005 12:00AM |
| 修稿时间： | 10 31 2005 12:00AM |
Preparation and Quality Control of PVP- I Film |
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| TIAN Rui,LI Qingeng,XU Qigui.Preparation and Quality Control of PVP- I Film[J].China Pharmacy,2006,17(6):430-431. |
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| Authors: | TIAN Rui LI Qingeng XU Qigui |
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| Institution: | Dept. of Pharmacy, Chongqing University of Medical Sciences, Chongqing 400016,China |
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| Abstract: | OBJECTIVE: To prepare PVP-I film agent of high water solubility and to establish a method for its quality control. METHODS: The film was prepared by mixing PVP-I,glycerol, distilled water and PVA05-88. The content of povidone iodine was determined with electric titration. The stability of the preparation stored in brown glass and colorless glass was investigated.RESULTS:The prepared film was integrated, clear and even in color and size. The average recovery was 99.03%(RSD=0.75%).The film stored in brown glass showed no evident changes in appearance and content within 60d, while that in colorless glass was found to have a decrease in content and yellowish appearance. CONCLUSION: The preparation technology is simple and method of quality control is accurate and reliable. |
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| Keywords: | PVP-I film Preparation Quality control Stability |
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