美沙酮维持治疗对海洛因依赖者情绪状态的影响

目的:了解美沙酮维持治疗(MMT)对海洛因依赖者情绪状态的影响,为维持治疗提供指导。方法:使用抑郁自评量表(CES-D),分别对131例参加美沙酮维持治疗一年以上的海洛因依赖者及120例来我院进行自愿戒毒的海洛因依赖者(对照组)急性脱毒前、后予以问卷调查,将两组人群的CES-D总评分及各单项评分予以比较、分析。结果:64.1%的美沙酮维持治疗者肯定有抑郁症状,对照组抑郁症状检出率为64.2%,两组抑郁症状患病率差异无统计学意义(P>0.05)。美沙酮维持治疗组常见抑郁症状依次为无愉快感(57.3%)、空虚感(56.5%)、自卑感(51.9%)、绝望感(45.0%),而对照组依次为自卑感(64.2%)、绝望感(59.2%)、无愉快感(55.8%)、空虚感(52.5%);对照组脱毒前、后抑郁症状改变差异无统计学意义(P>0.05);与对照组相比(治疗前后),MMT能显著改善自卑感、绝望感等抑郁症状,差异有统计学意义(P<0.05),但对无愉快感、空虚感无改善。结论:美沙酮维持治疗对抑郁状态总体无改善作用,但一定程度上具有部分改善抑郁情绪不同症状的作用,如降低患者的自卑感和绝望感。在治疗过程中,必须高度重视美沙酮维持治疗者的情绪状态以提高MMT治疗效果。

EFFECT OF METHADONE MAINTENANCE TREATMENT ON EMOTIONAL STATUS OF HEROIN DEPENDENT PATIENTS

Objective:To explore the effect of methadone maintenance treatment(MMT) on the emotional status of heroin dependent patients with heroin dependence and provide guidance for MMT.Methods: Patients including 131 cases on MMT over a year and 120 inpatients(as control) on detoxification voluntarily were assessed by CES-D.The results were analyzed and compared.Results:Obvious depression was discovered in 64.1% of MMT patients and 64.2% of the controls and no significant difference was observed between the two gro...