泡球蚴病动物模型的研究

将采自沙鼠体内的泡球蚴原头节,以1800个腹腔注入昆明种小鼠。依据感染率、血清抗体滴度、囊肿平均重量、囊蚴体积及囊蚴分布为指标,建立了泡球蚴病的小鼠动物模型。实验结果证明感染率为100％、囊蚴平均重量147.9mg/g体重、囊蚴平均体积11.4cm~3,感染鼠的血清抗体滴度显著高于对照组。用沙鼠多房棘球绦虫原头节一次腹腔接种,可引起小鼠继发性包虫感染的生物学和免疫学改变。从泡球蚴病小鼠接种到小鼠,感染率为84.6％,证明这是一种较好的进行药物筛选的动物模型。

AN ANIMAL MODEL FOR THE STUDY OF ALVEOLAR HYDATID DISEASE

The protoscolices of Echinococcus multilocularis (E.m.) collected from the Meriones unguiculatus were injected peritoneally into the mice, and each mouse received 1800 protoscolices. Four months later, the infection rate of alveolar hydatid cyst in mice was 100%, the average weight of the cysts was 147.9 mg/g body weight, the average volumn of the cysts in mice was 11. 38 cm3, and the indirect hemagglutination antibody titres of infected mice were significantly higher than those of the control group.Six hundred protoscolices of E.m.collected from mice were injected peritoneally into each of the mice of another group,and its infection rate was 84.6%. These results indicated that the inoculation of the protoscolices of E.m. in Meriones unguiculatus may cause the morphological and immunological changes, and it seems to be a better animal model of alveolar hydatid disease for drug screening.