内皮素、一氧化氮与肝硬化

肝硬化是各种慢性肝病发展到晚期的一种病理改变,肝功能损害、门静脉高压是其突出的表现。近年来,血管活性物质对肝脏疾病影响的研究已成为一个热点,特别是内皮素(ET)和一氧化氮(NO)。ET和NO是血管内皮细胞产生的生物调节因子,ET是由内皮细胞产生的一种多肽,具有缩血管和扩血管作用,而NO为一种强有力的血管内皮细胞舒张因子,具有强烈扩张血管作用。实验证实ET和NO与肝硬化的发生密切相关。

Endothelin,Nitric Oxide and Hepatic Cirrhosis

Hepatic cirrhosis is a pathological change of the advanced stage of a variety of chronic liver diseases.Hepatic dysfunction and portal hypertension are the outstanding performance.In recent years,the impact of vasoactive substances on liver disease has become a hot spot,especially endothelin（ET）and nitric oxide（NO）.ET and NO are the biology regulatory factors produced by vascular endothelial cell.ET is a peptide with vasoconstrictive and vasodilator effect produced by endothelial cells,and NO as a powerful endothe lium-defived relaxing factor,has a strong role in-dilation of blood vessels. Experiments confirmed that NO and ET and is closely related to the occurrence of liver cirrhosis.