小胶质细胞在肌萎缩侧索硬化症发病机制中的作用

肌萎缩侧索硬化症(amyotrophic lateral sclerosis,ALS)是以选择性运动神经元变性,进行性瘫痪为特点的慢性神经系统退行性疾病。关于此病的发病机制已有多种假说,近年来许多新的研究进展都是关于伴随着运动神经元死亡而产生的神经炎症反应,人们对于此病的认识也越来越深刻。小胶质细胞及其与运动神经元的相互作用在炎症和疾病的发生发展过程中扮演了重要角色,针对此提出的一系列治疗策略显示出了重要的临床价值。

Microglia in pathogenesis of amyotrophic lateral sclerosis

Amyotrophic lateral sclerosis is a chronic neurodegenerative disorder characterized by selective death of motor neurons and progressive paralysis. Many hypotheses have been proposed to explain its pathogenesis. In recent years, one of the most studied hypotheses was the inflammatory response accompanying the motor neuron death. Microglia and its interactions with motor neurons play important roles in the development and progression of the inflammatory responses and the disease itself, which results in different new and potent therapeutic strategies of great clinical value.