Paraganglia of the rat recurrent laryngeal nerve after long-term hypoxia: A morphometric and biochemical study |
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Authors: | Åke Dahlqvist Sten Hellström Bengt Carlsöö and Jean Marc Pequifnot |
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Institution: | (1) Department of Otolaryngology, University of Umeå, S-901 87, Umeä, Sweden;(2) Department of Anatomy, University of Umeå, S-901 87, Umeä, Sweden;(3) Department of Histology and Cell Biology, University of Umeå, S-901 87, Umeä, Sweden;(4) Laboratoire de Physiologie, Faculté de Médecine Grange-Blanche 8, 69673 Lyon Cédex 08, France |
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Abstract: | Summary Paraganglia of the recurrent laryngeal nerve of rats exposed to hypoxia (10±0.5% O2) for 3 weeks became enlarged in volume by 2.6-fold. The volume densities of blood vessel lumen and endothelial cells were unchanged. The enlargement of the paraganglia was mainly attributed to hypertrophy of the dense-cored vesicle-containing cell. Concerning the profile diameter of the vesicle, a unimodal distribution of dense-cored vesicle cells was found in both control and hypoxic paraganglia. The vesicle diameter increased by about 19%, whereas the numerical density of dense-cored vesicles and the vesicle volume density were unaltered after hypoxia.Recurrent laryngeal nerves assayed by a sensitive high performance liquid chromatography technique contained an average of 1.9pmol dopamine and 1.3pmol norepinephrine. Exposure to 2 weeks of hypoxia increased the dopamine level to 4.9pmol, whereas the norepinephrine content was unchanged. It is suggested from this study that the catecholamines determined are housed in the paraganglia of the recurrent laryngeal nerve. |
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