Polymorphism of the cell wall-anchoring domain of the autolysin-adhesin AtlE and its relationship to sequence type, as revealed by multilocus sequence typing of invasive and commensal Staphylococcus epidermidis strains |
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Authors: | Sivadon V Rottman M Quincampoix J-C Prunier E de Mazancourt P Bernard L Lortat-Jacob A Piriou P Judet T Gaillard J-L |
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Affiliation: | Laboratoire de Microbiologie, H?pital Raymond Poincaré, 104 Boulevard Raymond Poincaré 92380 Garches, France. valerie.sivadon-tardy@apr.ap-hop-paris.fr |
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Abstract: | We sequenced the adhesin-cell wall-anchoring domain of the atlE gene of 49 invasive and commensal Staphylococcus epidermidis strains. We identified 22 alleles, which could be separated into two main groups: group 1 (alleles 1 and 6 to 16, 32/49 strains) and group 2 (alleles 2 to 5 and 17 to 22, 17/49 strains). Allele 1 (the type strain sequence) was by far the most prevalent (21 of 49 strains). Multilocus sequence typing showed a clear relationship between the atlE allele and the sequence type (ST), with the "nosocomial" ST27 clone and closely related STs expressing group 1 alleles. |
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