单唾液酸四己糖神经节苷脂钠注射液不良事件及其救护措施

目的 探讨单唾液酸四己糖神经节苷脂钠注射液(GM1)致药品不良事件(ADE)的相关因素及其救护措施,为临床合理用药提供依据.方法 对湖南中医药大学第一附属医院2019年1月至2020年12月发生的12例GM1致ADE报告进行回顾性分析.结果 GM1致ADE多在用药后5 min～12 d内,主要表现为寒战、发热等全身性损...

Adverse drug events and treatment of monosialotetrahexosyl ganglioside sodium injection

Objective To investigate the related factors and treatment measures of adverse drug events (ADE) related to monosialotetrahexosyl ganglioside sodium injection(GM1), and to provide evidence for rational drug use in clinical practice.Methods A retrospective analysis was made of 12 cases with ADE caused by intravenous infusion of GM1 reported in The First Affiliated Hospital ofHunan University of Chinese Medicine from January 2019 to December 2020.Results The ADE caused by GM1 occurred mostly within 5 min to 12 days after medication. The main manifestations were shivering, fever and other systemic damage in 7 cases. The restwere skin damage in 3 cases, respiratory system and cardiovascular system damage in respective 2 cases, nervous system damage in 1case, and blurred vision in 1 case which was not mentioned in drug instruction. The above symptoms were obviously relieved after withdrawal of medication and symptomatic treatment.Conclusions Before using the injection clinically, patients should be asked abouttheir allergy history in detail, and 5% glucose injection should be selected preferentially as solvent with slow dripping. In the process ofmedication, the monitoring of ADE should be strengthened. Once adverse reactions are found, the drug should be withdrawn immediately, and symptomatic treatment such as 5 mg/10 mg intravenous drip of dexamethasone injection could be considered.